Movie for: The architecture of the 10-23 DNAzyme and its implications for DNA-mediated catalysis

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dc.contributor.authorChristoph, Gertzen
dc.contributor.authorJan, Borggräfe
dc.contributor.authorAldino, Viegas
dc.contributor.authorManuel, Etzkorn
dc.contributor.authorHolger, Gohlke
dc.date.accessioned2022-09-19T08:05:06Z
dc.date.available2022-09-19T08:05:06Z
dc.date.issued2022-09-19
dc.description.abstractUnderstanding the molecular features of catalytically active DNA sequences, so-called DNAzymes, is not only essential for our understanding of the fundamental properties of catalytic nucleic acids in general but may well be the key to unraveling their full potential via tailored modifications. Our recent findings contributed to the endeavor to assemble a mechanistic picture of DNA-mediated catalysis by providing high-resolution structural insights into the 10-23 DNAzyme (Dz) and exposing a complex interplay between the Dz´s unique molecular architecture, conformational plasticity, and dynamic modulation by metal ions as central elements of the DNA catalyst. To illustrate the sampled conformational space, the movie depicts one MD trajectory of the Dz:RNA complex.en_US
dc.description.sponsorshipH.G. is grateful for computational support and infrastructure provided by the "Zentrum für Informations- und Medientechnologie" (ZIM) at the Heinrich Heine University Düsseldorf and the John von Neumann Institute for Computing (NIC) (user ID: HKF7, VSK33).en_US
dc.identifier.urihttps://researchdata.hhu.de/handle/123456789/121
dc.identifier.urihttp://dx.doi.org/10.25838/d5p-37
dc.language.isoenen_US
dc.publisherN/Aen_US
dc.rightsAttribution-NonCommercial-NoDerivs 3.0 United States*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/us/*
dc.subjectstructural dynamicsen_US
dc.subject10-23 DNAzymeen_US
dc.subjectcatalysten_US
dc.subjectmolecular dynamics simulationsen_US
dc.titleMovie for: The architecture of the 10-23 DNAzyme and its implications for DNA-mediated catalysisen_US
dc.typeVideoen_US

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